Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells

Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells

Smenamides are an intriguing class of peptide/polyketide molecules of marine origin showing antiproliferative activity against lung cancer Calu-1 cells at nanomolar concentrations through a clear pro-apoptotic mechanism. To probe the role of the activity-determining structural features, the 16-epi-a...

Full description

Bibliographic Details
Main Authors: Alessia Caso, Ilaria Laurenzana, Daniela Lamorte, Stefania Trino, Germana Esposito, Vincenzo Piccialli, Valeria Costantino
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Marine Drugs
Subjects:
smenamides
marine natural products
peptide/polyketide molecules
synthetic analogues
functional-analogues
antiproliferative activity
MM cell line
Online Access:http://www.mdpi.com/1660-3397/16/6/206

Internet

http://www.mdpi.com/1660-3397/16/6/206

Similar Items