TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

TGF-β is widely held to be critical for the maintenance and function of regulatory T (T(reg)) cells and thus peripheral tolerance. This is highlighted by constitutive ablation of TGF-β receptor (TR) during thymic development in mice, which leads to a lethal autoimmune syndrome. Here we describe that...

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Bibliographic Details
Main Authors: Anna Sledzińska, Saskia Hemmers, Florian Mair, Oliver Gorka, Jürgen Ruland, Lynsey Fairbairn, Anja Nissler, Werner Müller, Ari Waisman, Burkhard Becher, Thorsten Buch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24115907/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24115907/?tool=EBI

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