Doxorubicin Induces Apoptosis by Activation of Caspase-3 in Cultured Cardiomyocytes In Vitro and Rat Cardiac Ventricles In Vivo

Doxorubicin Induces Apoptosis by Activation of Caspase-3 in Cultured Cardiomyocytes In Vitro and Rat Cardiac Ventricles In Vivo

Abstract.: Doxorubicin (DOX) is widely used to treat patients suffering from cancer, but the usage for patients is limited because of the dose-dependent cardiotoxicity. We hypothesized that DOX induces apoptosis through caspase activation in cardiomyocytes, and we examined this hypothesis using both...

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Bibliographic Details
Main Authors: Ueno Michihiko, Kakinuma Yoshihiko, Yuhki Koh-ichi, Murakoshi Nobuyuki, Iemitsu Motoyuki, Miyauchi Takashi, Yamaguchi Iwao
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319344603

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http://www.sciencedirect.com/science/article/pii/S1347861319344603

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