Targeting the Hedgehog Pathway in Pediatric Medulloblastoma

Medulloblastoma (MB), a primitive neuroectomal tumor of the cerebellum, is the most common malignant pediatric brain tumor. The cause of MB is largely unknown, but aberrant activation of Hedgehog (Hh) pathway is responsible for ~30% of MB. Despite aggressive treatment with surgical resection, radiat...

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Bibliographic Details
Main Authors: Sherri Y. Huang, Jer-Yen Yang
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/7/4/0880