Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.

Bibliographic Details
Main Authors: Constantin Cretu, Patricia Gee, Xiang Liu, Anant Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh, Andrew Cook, Melissa Jurica, Nicholas A. Larsen, Vladimir Pena
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24741-1

Internet

https://doi.org/10.1038/s41467-021-24741-1

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