Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.

Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.

Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which arise and propagate during very early stages of mammal...

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Bibliographic Details
Main Authors: Yunhai Luo, Suzanne A Hartford, Ruizhu Zeng, Teresa L Southard, Naoko Shima, John C Schimenti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4091704?pdf=render

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http://europepmc.org/articles/PMC4091704?pdf=render

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