The Absence of Serotonin in the Brain Alters Acute Stress Responsiveness by Interfering With the Genomic Function of the Glucocorticoid Receptors

The Absence of Serotonin in the Brain Alters Acute Stress Responsiveness by Interfering With the Genomic Function of the Glucocorticoid Receptors

Alterations in serotonergic transmission have been related to a major predisposition to develop psychiatric pathologies, such as depression. We took advantage of tryptophan hydroxylase (TPH) 2 deficient rats, characterized by a complete absence of serotonin in the brain, to evaluate whether a vulner...

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Bibliographic Details
Main Authors: Giulia Sbrini, Paola Brivio, Polina Mineva Peeva, Mihail Todiras, Michael Bader, Natalia Alenina, Francesca Calabrese
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
serotonin
tryptophan hydroxylase
HPA axis
glucocorticoid
clock genes
rats
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00128/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00128/full

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