Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening

Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening

We describe a ligand-based approach towards compounds with more specific targeting for Burkitt’s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conform...

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Bibliographic Details
Main Authors: Martina Gobec, Izidor Sosič, Boris Brus, Aleš Obreza, Stanislav Gobec, Irena Mlinarič-Raščan
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
Burkitt’s lymphoma
ligand-based
similarity search
selectivity
Online Access:http://www.mdpi.com/1420-3049/19/11/19209

Internet

http://www.mdpi.com/1420-3049/19/11/19209

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