Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

Abstract Background Breast cancer is the second leading cause of cancer deaths in the USA. Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer with high rates of metastasis, tumor recurrence, and resistance to therapeutics. Obesity, defined by a high body mass in...

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Bibliographic Details
Main Authors: Rachel A. Sabol, Annie C. Bowles, Alex Côté, Rachel Wise, Benjamen O’Donnell, Margarite D. Matossian, Fokhrul M. Hossain, Hope E. Burks, Luis Del Valle, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow, Bruce A. Bunnell
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Breast Cancer Research
Subjects:
Adipose stem cells
Obesity
Triple-negative breast cancer
Metastasis
Patient-derived xenograft
Online Access:http://link.springer.com/article/10.1186/s13058-019-1153-9

Internet

http://link.springer.com/article/10.1186/s13058-019-1153-9

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