Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases.

Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases.

It has been recognized that cells do not respond equally to ultraviolet (UV) radiation but it is not clear whether this is due to genetic, biochemical or structural differences of the cells. We have a novel cybrid (cytoplasmic hybrids) model that allows us to analyze the contribution of mitochondria...

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Bibliographic Details
Main Authors: Deepika Malik, Tiffany Hsu, Payam Falatoonzadeh, Javier Cáceres-del-Carpio, Mohamed Tarek, Marilyn Chwa, Shari R Atilano, Claudio Ramirez, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar, M Cristina Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4053329?pdf=render

Internet

http://europepmc.org/articles/PMC4053329?pdf=render

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