Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation

Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation

Adverse cardiovascular events are a leading nonmalignant cause of morbidity and mortality among cancer survivors who have been exposed to ionizing radiation (IR), but the exact mechanism of the cardiovascular complications induced by IR remains unclear. In this study we investigated the potential ro...

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Bibliographic Details
Main Authors: Hang Thi Vu, Sivareddy Kotla, Kyung Ae Ko, Yuka Fujii, Yunting Tao, Jan Medina, Tamlyn Thomas, Megumi Hada, Anil K. Sood, Pankaj Kumar Singh, Sarah A. Milgrom, Sunil Krishnan, Keigi Fujiwara, Nhat-Tu Le, Jun-Ichi Abe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Ionizing radiation
p90RSK
ERK5
EC inflammation
EC apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fcvm.2018.00023/full

Internet

http://journal.frontiersin.org/article/10.3389/fcvm.2018.00023/full

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