Interpretation of T cell states from single-cell transcriptomics data using reference atlases

One challenge of single cell RNA sequencing analysis is how to consistently identify cell subtypes and states across different datasets. Here the authors propose the use of a reference single-cell atlas as a stable system of coordinates to characterize T cell states across studies, diseases and spec...

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Bibliographic Details
Main Authors: Massimo Andreatta, Jesus Corria-Osorio, Sören Müller, Rafael Cubas, George Coukos, Santiago J. Carmona
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23324-4