Recombinant acylation stimulating protein administration to C3-/- mice increases insulin resistance via adipocyte inflammatory mechanisms.

Recombinant acylation stimulating protein administration to C3-/- mice increases insulin resistance via adipocyte inflammatory mechanisms.

Complement 3 (C3), a key component of the innate immune system, is involved in early inflammatory responses. Acylation stimulating protein (ASP; aka C3adesArg), a C3 cleavage product, is produced in adipose tissue and stimulates lipid storage. We hypothesized that, depending on the diet, chronic ASP...

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Bibliographic Details
Main Authors: Mercedes Nancy Munkonda, Marc Lapointe, Pierre Miegueu, Christian Roy, Danny Gauvreau, Denis Richard, Katherine Cianflone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3466186?pdf=render

Internet

http://europepmc.org/articles/PMC3466186?pdf=render

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