Transgenic expression of human FGF-1 protects against hypoxic–ischemic injury in perinatal brain by intervening at caspase-XIAP signaling cascades

Transgenic expression of human FGF-1 protects against hypoxic–ischemic injury in perinatal brain by intervening at caspase-XIAP signaling cascades

Perinatal hypoxia–ischemia (HI) is a major cause of neurological disability and mortality in infant and children. In the present study, we explored the neuroprotective efficacy of FGF-1 in a rat model of perinatal HI. Carotid ligation combined with hypoxia caused marked infarctions in the ipsilatera...

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Bibliographic Details
Main Authors: Juliet C. Russell, Nicholas Szuflita, Rina Khatri, John Laterra, Mir Ahamed Hossain
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
Perinatal brain
Hypoxic–ischemic injury
Neuroprotection
FGF-1
Apoptosis
Necrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000106

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http://www.sciencedirect.com/science/article/pii/S0969996106000106

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