Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice

Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice

Using an established mouse model of human periventricular leukomalacia, we investigated whether EPO could reduce excitotoxic damage. When administered 1 h following intracerebral injection of 10 μg ibotenic acid at day 5 of life, both a single injection of EPO (5000 IU/kg bw) and repetitive administ...

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Bibliographic Details
Main Authors: Matthias Keller, Jingli Yang, Elke Griesmaier, Agnieszka Gorna, Gergely Sarkozy, Martina Urbanek, Pierre Gressens, Georg Simbruner
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Brain injury
Newborn
Excitotoxicity
Erythropoietin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001720

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http://www.sciencedirect.com/science/article/pii/S0969996106001720

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