Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming.
Mobile group II introns retrohome by an RNP-based mechanism in which the intron RNA reverse splices into a DNA site and is reverse transcribed by the associated intron-encoded protein. The resulting intron cDNA is then integrated into the genome by cellular mechanisms that have remained unclear. Her...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-04-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3636086?pdf=render |