Protective function and durability of mouse lymph node-resident memory CD8+ T cells

Protective function and durability of mouse lymph node-resident memory CD8+ T cells

Protective lung tissue-resident memory CD8+T cells (Trm) form after influenza A virus (IAV) infection. We show that IAV infection of mice generates CD69+CD103+and other memory CD8+T cell populations in lung-draining mediastinal lymph nodes (mLNs) from circulating naive or memory CD8+T cells. Repeate...

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Bibliographic Details
Main Authors: Scott M Anthony, Natalija Van Braeckel-Budimir, Steven J Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M Hartwig, Isaac J Jensen, Steven M Varga, Noah S Butler, Hai-Hui Xue, Vladimir P Badovinac, John T Harty
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
CD8+ T cell
virus infection
lymph node
lung
CD8+ T cell resident memory
repeated antigen exposure
Online Access:https://elifesciences.org/articles/68662

Internet

https://elifesciences.org/articles/68662

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