NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart

NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart

BackgroundNOD-like receptors (NLR) are intracellular sensors of the innate immune system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia-reperfusion injury (IRI) and metabolism. No information is available on a possible role of anti-inflammatory NLRs on IRI and metabo...

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Bibliographic Details
Main Authors: Hong Zhang, Yang Xiao, Rianne Nederlof, Diane Bakker, Pengbo Zhang, Stephen E. Girardin, Markus W. Hollmann, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Richard G. Kibbey, Coert J. Zuurbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
cardiac metabolism
oxygen consumption
innate immunity
infarct size
duration of ischemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.591815/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.591815/full

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