Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In...

Full description

Bibliographic Details
Main Authors: Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
protein structure
X-ray crystallography
antimicrobial peptide
phospholipid
fungus
Online Access:https://elifesciences.org/articles/01808

Internet

https://elifesciences.org/articles/01808

Similar Items