Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis

Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis

B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R ex...

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Bibliographic Details
Main Authors: Elizabeth M. Dam, Alison C. Maier, Anne M. Hocking, Jeffrey Carlin, Bernard Ng, Jane H. Buckner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
B cells
IL-21R
specificity protein 1
IL-6
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01978/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01978/full

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