Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells

Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells

Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell...

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Bibliographic Details
Main Authors: Motomasa Kobayashi, Toshiyuki Sakai, Yoshihiro Sowa, Shunji Aoki, Dexin Kong
Format: Article
Language:English
Published: MDPI AG 2008-08-01
Series:Marine Drugs
Subjects:
Smenospongine
G1 arrest
apoptosis
leukemia cells
p21
Rb
Online Access:http://www.mdpi.com/1660-3397/6/3/480/

Internet

http://www.mdpi.com/1660-3397/6/3/480/

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