Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens

Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens

Abstract Background Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lea...

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Bibliographic Details
Main Authors: Phuong T. Lam, Stephanie L. Padula, Thanh V. Hoang, Justin E. Poth, Lin Liu, Chun Liang, Adam S. LeFever, Lindsay M. Wallace, Ruth Ashery-Padan, Penny K. Riggs, Jordan E. Shields, Ohad Shaham, Sheldon Rowan, Nadean L. Brown, Tom Glaser, Michael L. Robinson
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Human Genomics
Subjects:
Cre recombinase
Lens development
Transgenic mice
Online Access:http://link.springer.com/article/10.1186/s40246-019-0192-8

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http://link.springer.com/article/10.1186/s40246-019-0192-8

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