Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation

Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation

Oncolytic virus therapy can increase the immunogenicity of tumors and remodel the immunosuppressive tumor microenvironment, leading to an increased antitumor response to immune-checkpoint inhibitors. Here, we investigated the therapeutic potential of G47Δ, a third-generation oncolytic herpes simplex...

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Bibliographic Details
Main Authors: Kotaro Sugawara, Miwako Iwai, Hirotaka Ito, Minoru Tanaka, Yasuyuki Seto, Tomoki Todo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus therapy
G47Δ
CTLA-4
PD-1
immune-checkpoint inhibitors
herpes simplex virus type 1
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052100070X

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http://www.sciencedirect.com/science/article/pii/S237277052100070X

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