Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium

Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been widely used for disease modeling and drug cardiotoxicity screening. To this end, we recently developed human cardiac organoids (hCOs) for modeling human myocardium. Here, we perform a transcriptomic analysis of various...

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Bibliographic Details
Main Authors: Charles M. Kerr, Dylan Richards, Donald R. Menick, Kristine Y. Deleon-Pennell, Ying Mei
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
hiPSC-CMs
human cardiac organoids
transcriptome
engineered heart tissue
human myocardium
3D culture
Online Access:https://www.mdpi.com/1422-0067/22/16/8482

Internet

https://www.mdpi.com/1422-0067/22/16/8482

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