Interactions among Polycomb domains are guided by chromosome architecture.

Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...

Full description

Bibliographic Details
Main Authors: Bas Tolhuis, Marleen Blom, Ron M Kerkhoven, Ludo Pagie, Hans Teunissen, Marja Nieuwland, Marieke Simonis, Wouter de Laat, Maarten van Lohuizen, Bas van Steensel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3063757?pdf=render