Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule

Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule

Herpesviral nuclear egress is a regulated process shared by all family members, ensuring the efficient cytoplasmic release of viral capsids. In the case of human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50-pUL53 heterodimer that builds hexameric lattice...

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Bibliographic Details
Main Authors: Jintawee Kicuntod, Sewar Alkhashrom, Sigrun Häge, Benedikt Diewald, Regina Müller, Friedrich Hahn, Peter Lischka, Heinrich Sticht, Jutta Eichler, Manfred Marschall
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
human cytomegalovirus
core nuclear egress complex (NEC)
in vitro NEC assembly assay
core NEC coimmunoprecipitation
oligomeric interaction properties
associated cellular factors
Online Access:https://www.mdpi.com/1999-4915/13/3/462

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https://www.mdpi.com/1999-4915/13/3/462

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