Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2.

Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2.

Fosmidomycin is a time-dependent nanomolar inhibitor of methylerythritol phosphate (MEP) synthase, which is the enzyme that catalyzes the first committed step in the MEP pathway to isoprenoids. Importantly, fosmidomycin is one of only a few MEP pathway-specific inhibitors that exhibits antimicrobial...

Full description

Bibliographic Details
Main Authors: David T Fox, Emily N Schmidt, Hongzhao Tian, Suraj Dhungana, Michael C Valentine, Nicole V Warrington, Paul D Phillips, Kellan B Finney, Emily K Cope, Jeff G Leid, Charles A Testa, Andrew T Koppisch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3994034?pdf=render

Internet

http://europepmc.org/articles/PMC3994034?pdf=render

Similar Items