Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression

Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression

Low levels of transgenic mouse apolipoprotein E (apoE) suppress atherosclerosis in apoE knockout (apoE−/−) mice without normalizing plasma cholesterol. To test whether this is due to facilitation of cholesterol efflux from the vessel wall, we produced apoA-I−/−/apoE−/− mice with or without the trans...

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Bibliographic Details
Main Authors: Fayanne E. Thorngate, Patricia G. Yancey, Ginny Kellner-Weibel, Lawrence L. Rudel, George H. Rothblat, David L. Williams
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein E
atherosclerosis
cholesterol efflux
ABCA1
apolipoprotein A-IV
cholesteryl ester
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319519

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http://www.sciencedirect.com/science/article/pii/S0022227520319519

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