Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway

Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway

Objective: This study aimed to assess the effect and mechanism of SS31 on cisplatin-induced acute kidney injury (CP-AKI) both in vivo and in vitro. Method: Male mices and HK-2 cells were treated using cisplatin to establish models of CP-AKI. 32 C57BL/6 mices were randomly divided into four groups (c...

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Bibliographic Details
Main Authors: Shi-kun Yang, Ya-chun Han, Jin-rong He, Ming Yang, Wei Zhang, Ming Zhan, Ai-mei Li, Liu Li, Na-Song, Yu-ting Liu, Xue-qin Wu, Qin Zhang, Jian-wen Wang, Hao Zhang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
SS-31
Mitochondria
Cisplatin
Acute kidney injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307149

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http://www.sciencedirect.com/science/article/pii/S0753332220307149

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