Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling

Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling

Ischemia/reperfusion injury holds a key position in many pathological conditions such as acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized that besides a reported disproportional activation of vasoconstrictor response, hypoxia/reoxygenation (H/R) adversely...

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Bibliographic Details
Main Authors: Diana Braun, Christa Zollbrecht, Stefanie Dietze, Rudolf Schubert, Stefan Golz, Holger Summer, Pontus B. Persson, Mattias Carlström, Marion Ludwig, Andreas Patzak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
hypoxia
ischemia/reperfusion injury
nitric oxide
cGMP
sGC
vascular smooth muscle
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00480/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00480/full

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