Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

Abstract Background The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5 years. Most recurrences occur in the peritoneal cavity, s...

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Bibliographic Details
Main Authors: Jennifer Pasquier, Fabien Vidal, Jessica Hoarau-Véchot, Claire Bonneau, Emile Daraï, Cyril Touboul, Arash Rafii
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
Chemoresistance
Surgery
Tumor microenvironment
IL8
Online Access:http://link.springer.com/article/10.1186/s12967-018-1643-z

Internet

http://link.springer.com/article/10.1186/s12967-018-1643-z

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