Ultrafast Backbone Protonation in Channelrhodopsin-1 Captured by Polarization Resolved Fs Vis-pump—IR-Probe Spectroscopy and Computational Methods

Ultrafast Backbone Protonation in Channelrhodopsin-1 Captured by Polarization Resolved Fs Vis-pump—IR-Probe Spectroscopy and Computational Methods

Channelrhodopsins (ChR) are light-gated ion-channels heavily used in optogenetics. Upon light excitation an ultrafast all-<i>trans</i> to 13-<i>cis</i> isomerization of the retinal chromophore takes place. It is still uncertain by what means this reaction leads to further pro...

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Bibliographic Details
Main Authors: Till Stensitzki, Suliman Adam, Ramona Schlesinger, Igor Schapiro, Karsten Heyne
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
photoisomerization
retinal
optogenetics
vibrational spectroscopy
qm/mm calculations
protein dynamics
counter-ion
proton transfer
proton back-transfer
channelrhodopsin
Online Access:https://www.mdpi.com/1420-3049/25/4/848

Internet

https://www.mdpi.com/1420-3049/25/4/848

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