Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Abstract Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activated protein kinase (AMPK), a molecule that recently emerged as a potential therapeutic target for i...

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Bibliographic Details
Main Authors: Maria Grissi, Cédric Boudot, Maryam Assem, Alexandre Candellier, Mathilde Lando, Sabrina Poirot-Leclercq, Agnès Boullier, Youssef Bennis, Gaëlle Lenglet, Carine Avondo, Jean-Daniel Lalau, Gabriel Choukroun, Ziad A. Massy, Saïd Kamel, Jean-Marc Chillon, Lucie Hénaut
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86905-9

Internet

https://doi.org/10.1038/s41598-021-86905-9

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