Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein

Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein

Abstract Last decade witnessed an enormous progress in generating authentic infectious prions or PrPSc in vitro using recombinant prion protein (rPrP). Previous work established that rPrP that lacks posttranslational modification is able to support replication of highly infectious PrPSc with assista...

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Bibliographic Details
Main Authors: Natallia Makarava, Regina Savtchenko, Peter Lasch, Michael Beekes, Ilia V. Baskakov
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Acta Neuropathologica Communications
Subjects:
Prions
Prion diseases
Prion strain
Replication cofactors
Recombinant prion protein
Online Access:http://link.springer.com/article/10.1186/s40478-018-0597-y

Internet

http://link.springer.com/article/10.1186/s40478-018-0597-y

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