Generation of a Novel Mesothelin-Targeted Oncolytic <i>Herpes</i> Virus and Implemented Strategies for Manufacturing

Generation of a Novel Mesothelin-Targeted Oncolytic <i>Herpes</i> Virus and Implemented Strategies for Manufacturing

Background: HER2-based retargeted viruses are in advanced phases of preclinical development of breast cancer models. Mesothelin (MSLN) is a cell-surface tumor antigen expressed in different subtypes of breast and non-breast cancer. Its recent identification as a marker of some triple-negative breast...

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Bibliographic Details
Main Authors: Guendalina Froechlich, Chiara Gentile, Luigia Infante, Carmen Caiazza, Pasqualina Pagano, Sarah Scatigna, Gabriella Cotugno, Anna Morena D’Alise, Armin Lahm, Elisa Scarselli, Alfredo Nicosia, Massimo Mallardo, Emanuele Sasso, Nicola Zambrano
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
oncolytic virus
triple negative breast cancer
malignant mesothelioma
targeted therapy
MSLN
Online Access:https://www.mdpi.com/1422-0067/22/2/477

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https://www.mdpi.com/1422-0067/22/2/477

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