Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity. Both compounds can be obtained through the chemical condensation of their precursors vindoline and cath...

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Bibliographic Details
Main Authors: Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
alkaloids
<i>Catharanthus roseus</i>
metabolic engineering
O-methyltransferase
Online Access:https://www.mdpi.com/1420-3049/26/12/3596

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https://www.mdpi.com/1420-3049/26/12/3596

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