The weakness of fragility index exposed in an analysis of the traumatic brain injury management guidelines: A meta-epidemiological and simulation study.

OBJECTIVES:To perform fragility index (FI) analysis on the evidence that forms the basis of the guidelines for the management of severe traumatic brain injury (TBI), and develop a deeper understanding of the pitfalls associated with FI. DESIGN:Meta-epidemiological analysis and numerical simulations....

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Bibliographic Details
Main Authors: Thomas M Condon, Richard W Sexton, Adam J Wells, Minh-Son To
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237879