Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Abstract Background Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of the inflammatory process. NAMPT inhibition has a beneficial effect in the treatment of a variety of inflammatory diseases. However, it remains unclear wh...

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Bibliographic Details
Main Authors: Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang, Shi-Jye Chu
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Respiratory Research
Subjects:
Acute lung injury
Ischemia-reperfusion
Visfatin
Nicotinamide phosphoribosyltransferase
pre-B cell colony-enhancing factor
Online Access:http://link.springer.com/article/10.1186/s12931-017-0557-2

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http://link.springer.com/article/10.1186/s12931-017-0557-2

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