Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen c...

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Bibliographic Details
Main Authors: Fatma Berri, Guus F Rimmelzwaan, Michel Hanss, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Vuong B Lê, Stella E Vogelzang-van Trierum, Patrica Gil, Eric Camerer, Dominique Martinez, Bruno Lina, Roger Lijnen, Peter Carmeliet, Béatrice Riteau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555246/?tool=EBI

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