Peripheral T Cell Depletion by FTY720 Exacerbates Hypoxic-Ischemic Brain Injury in Neonatal Mice

Peripheral T Cell Depletion by FTY720 Exacerbates Hypoxic-Ischemic Brain Injury in Neonatal Mice

Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term morbidity and mortality. Emerging evidence from neonatal brain injury models suggests a detrimental role for peripheral lymphocytes. The immunomodulatory substance FTY720, a sphingosine-1-phosphate recepto...

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Bibliographic Details
Main Authors: Josephine Herz, Christian Köster, Marius Crasmöller, Hanna Abberger, Wiebke Hansen, Ursula Felderhoff-Müser, Ivo Bendix
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
neonatal hypoxia ischemia
birth asphyxia
brain injury
T cells
FTY720
immune cell infiltration
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01696/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01696/full

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