Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice

Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice

Alzheimer’s disease (AD) is a severe neurodegenerative disorder of the central nervous system (CNS) characterized by neuron loss and dementia. Previous abundant evidence demonstrates that the first critical step in the course of AD is the state of oxidative stress and the neuronal loss is closely re...

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Bibliographic Details
Main Authors: Wenyue Wei, Yuyin Wang, Jing Zhang, Qingfang Gu, Xiaoqin Liu, Lijuan Song, Zhi Chai, Minfang Guo, Jiezhong Yu, Cungen Ma
Format: Article
Language:English
Published: Termedia Publishing House 2021-03-01
Series:Folia Neuropathologica
Subjects:
alzheimer’s disease
oxidative stress
apoptosis
rock
mapk
nrf2.
Online Access:https://www.termedia.pl/Fasudil-ameliorates-cognitive-deficits-oxidative-stress-r-nand-neuronal-apoptosis-via-inhibiting-ROCK-MAPK-r-nand-activating-Nrf2-signalling-pathways-in-APP-PS1-mice,20,43762,1,1.html

Internet

https://www.termedia.pl/Fasudil-ameliorates-cognitive-deficits-oxidative-stress-r-nand-neuronal-apoptosis-via-inhibiting-ROCK-MAPK-r-nand-activating-Nrf2-signalling-pathways-in-APP-PS1-mice,20,43762,1,1.html

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