Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response

Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response

Metastatic melanoma is an aggressive type of skin cancer leading half of the patients to death within 8–10 months after diagnosis. Kinins are peptides that interact with B1 and B2 receptors playing diverse biological roles. We investigated whether treatment with B1 receptor agonist, des-Arg9-bradyki...

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Bibliographic Details
Main Authors: Andrea Gutierrez Maria, Patrícia Dillemburg-Pilla, Marina de Toledo Durand, Elaine Medeiros Floriano, Adriana Oliveira Manfiolli, Simone Gusmão Ramos, João Bosco Pesquero, Clara Nahmias, Claudio M. Costa-Neto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
melanoma
des-Arg9-bradykinin
B1 receptor
immune response
inflammation
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01106/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01106/full

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