Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.

Bibliographic Details
Main Authors: Yuan Zhang, Lulu Liu, Shengjie Guo, Jinghui Song, Chenxu Zhu, Zongwei Yue, Wensheng Wei, Chengqi Yi
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00860-6

Internet

https://doi.org/10.1038/s41467-017-00860-6

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