Up-Regulated Expression of Pro-Apoptotic Long Noncoding RNA lincRNA-p21 with Enhanced Cell Apoptosis in Lupus Nephritis

Up-Regulated Expression of Pro-Apoptotic Long Noncoding RNA lincRNA-p21 with Enhanced Cell Apoptosis in Lupus Nephritis

Accelerated cell apoptosis with dysregulated long noncoding RNAs is the crucial pathogenesis in lupus nephritis (LN). Pro-apoptotic lincRNA-p21 was studied in LN patients, cell lines with lentivirus-mediated overexpression and CRISPR interference (CRISPRi)-conducted repression, and a mouse model. Cl...

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Bibliographic Details
Main Authors: Yi-Cheng Chen, Pin-Yu Kuo, Yu-Chi Chou, Hao-Earn Chong, Yu-Tung Hsieh, Mei-Lin Yang, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
lupus nephritis
cell apoptosis
lincRNA-p21
CRISPR interference
Online Access:https://www.mdpi.com/1422-0067/22/1/301

Internet

https://www.mdpi.com/1422-0067/22/1/301

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