Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL

Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL

NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL cells with special emphasis on the individual roles of t...

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Bibliographic Details
Main Authors: Rainer Hubmann, Susanne Schnabl, Mohammad Araghi, Christian Schmidl, André F. Rendeiro, Martin Hilgarth, Dita Demirtas, Farghaly Ali, Philipp B. Staber, Peter Valent, Christoph Zielinski, Ulrich Jäger, Medhat Shehata
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
chronic lymphocytic leukemia (CLL)
<i>NOTCH2</i>
<i>NOTCH3</i>
<i>FCER2</i> (CD23)
<i>NR4A1</i>
gliotoxin
Online Access:https://www.mdpi.com/2073-4409/9/6/1484

Internet

https://www.mdpi.com/2073-4409/9/6/1484

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