Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia.

Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia.

Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/-) mice were developed to investigate the effect of arginase-1 related arginine depletion on NOS2-...

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Bibliographic Details
Main Authors: Karolina A P Wijnands, Marten A Hoeksema, Dennis M Meesters, Nynke M S van den Akker, Daniel G M Molin, Jacob J Briedé, Mitrajit Ghosh, S Eleonore Köhler, Marc A M J van Zandvoort, Menno P J de Winther, Wim A Buurman, Wouter H Lamers, Martijn Poeze
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897658?pdf=render

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http://europepmc.org/articles/PMC3897658?pdf=render

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