Melatonin Suppresses Hypoxia-Induced Migration of HUVECs via Inhibition of ERK/Rac1 Activation

Melatonin Suppresses Hypoxia-Induced Migration of HUVECs via Inhibition of ERK/Rac1 Activation

Melatonin, a naturally-occurring hormone, possesses antioxidant properties and ameliorates vascular endothelial dysfunction. In this study, we evaluate the impact of melatonin on the migratory capability of human umbilical vein endothelial cells (HUVECs) to hypoxia and further investigate whether...

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Bibliographic Details
Main Authors: Ling Yang, Jianchao Zheng, Rui Xu, Yujie Zhang, Luo Gu, Jing Dong, Yichao Zhu, Ruijue Zhou, Lu Zheng, Xiaoying Zhang, Jun Du
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
ERK
Rac1
HIF-1α
migration
HUVEC
melatonin
Online Access:http://www.mdpi.com/1422-0067/15/8/14102

Internet

http://www.mdpi.com/1422-0067/15/8/14102

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