It is time for top-down venomics

Abstract The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoforms, herein called toxiforms, because of the protein inference problem. Top-down pro...

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Bibliographic Details
Main Authors: Rafael D. Melani, Fabio C. S. Nogueira, Gilberto B. Domont
Format: Article
Language:English
Published: SciELO 2017-10-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40409-017-0135-6