Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays
Nutlin is a family of p53-targeting drugs. It is able to bind to Mdm2, thereby accelerate the accumulation of p53 that is a prominent tumor suppressor. An integrated module of the Nutlin PBK and p53 pathway is composed of positive feedback mediated by Mdm2 mRNA as well as the drug Nutlin and negativ...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2021-05-01
|
| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | http://www.aimspress.com/article/doi/10.3934/mbe.2021173?viewType=HTML |