Botch Is a γ-Glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch

Botch Is a γ-Glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch

Botch promotes embryonic neurogenesis by inhibiting the initial S1 furin-like cleavage step of Notch maturation. The biochemical process by which Botch inhibits Notch maturation is not known. Here, we show that Botch has γ-glutamyl cyclotransferase (GGCT) activity that deglycinates Notch, which prev...

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Bibliographic Details
Main Authors: Zhikai Chi, Sean T. Byrne, Andrew Dolinko, Maged M. Harraz, Min-Sik Kim, George Umanah, Jun Zhong, Rong Chen, Jianmin Zhang, Jinchong Xu, Li Chen, Akhilesh Pandey, Ted M. Dawson, Valina L. Dawson
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002459

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http://www.sciencedirect.com/science/article/pii/S2211124714002459

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